Prion-Like Behavior and Tau-dependent Cytotoxicity of Pyroglutamylated β-Amyloid

Extracellular plaques of β-amyloid (Aβ) and intraneuronal neurofibrillary tangles made from tau are the histopathological signatures of Alzheimer’s disease (AD). Plaques comprise Aβ fibrils that assemble from monomeric and oligomeric intermediates, and are prognostic indicators of AD. Despite the si...

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Detalles Bibliográficos
Autores principales: Nussbaum, Justin M., Schilling, Stephan, Cynis, Holger, Silva, Antonia, Swanson, Eric, Wangsanut, Tanaporn, Tayler, Kaycie, Wiltgen, Brian, Hatami, Asa, Rönicke, Raik, Reymann, Klaus, Hutter-Paier, Birgit, Alexandru, Anca, Jagla, Wolfgang, Graubner, Sigrid, Glabe, Charles G., Demuth, Hans-Ulrich, Bloom, George S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367389/
https://www.ncbi.nlm.nih.gov/pubmed/22660329
http://dx.doi.org/10.1038/nature11060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367389/
https://www.ncbi.nlm.nih.gov/pubmed/22660329
http://dx.doi.org/10.1038/nature11060

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