Folding Circular Permutants of IL-1β: Route Selection Driven by Functional Frustration

Interleukin-1β (IL-1β) is the cytokine crucial to inflammatory and immune response. Two dominant routes are populated in the folding to native structure. These distinct routes are a result of the competition between early packing of the functional loops versus closure of the β-barrel to achieve effi...

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Detalles Bibliográficos
Autores principales: Capraro, Dominique T., Gosavi, Shachi, Roy, Melinda, Onuchic, José N., Jennings, Patricia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367917/
https://www.ncbi.nlm.nih.gov/pubmed/22693643
http://dx.doi.org/10.1371/journal.pone.0038512

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367917/
https://www.ncbi.nlm.nih.gov/pubmed/22693643
http://dx.doi.org/10.1371/journal.pone.0038512

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