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Folding Circular Permutants of IL-1β: Route Selection Driven by Functional Frustration
Interleukin-1β (IL-1β) is the cytokine crucial to inflammatory and immune response. Two dominant routes are populated in the folding to native structure. These distinct routes are a result of the competition between early packing of the functional loops versus closure of the β-barrel to achieve effi...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367917/ https://www.ncbi.nlm.nih.gov/pubmed/22693643 http://dx.doi.org/10.1371/journal.pone.0038512 |