A Two-Step Mechanism for Cell Fate Decision by Coordination of Nuclear and Mitochondrial p53 Activities

The tumor suppressor p53 has a crucial role in the DNA damage response. Here, we proposed an integrated model of the p53 network and explored how the nuclear and mitochondrial p53 pathways are coordinated to determine cell fates after [Image: see text]-irradiation in radiosensitive tissues. Using nu...

Descripción completa

Detalles Bibliográficos
Autores principales: Tian, Xiao-Jun, Liu, Feng, Zhang, Xiao-Peng, Li, Jun, Wang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367989/
https://www.ncbi.nlm.nih.gov/pubmed/22679490
http://dx.doi.org/10.1371/journal.pone.0038164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367989/
https://www.ncbi.nlm.nih.gov/pubmed/22679490
http://dx.doi.org/10.1371/journal.pone.0038164

Ejemplares similares