Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis

A high-throughput screen against PknB, an essential serine–threonine protein kinase present in Mycobacterium tuberculosis (M. tuberculosis), allowed the identification of an aminoquinazoline inhibitor which was used as a starting point for SAR investigations. Although a significant improvement in en...

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Detalles Bibliográficos
Autores principales: Chapman, Timothy M., Bouloc, Nathalie, Buxton, Roger S., Chugh, Jasveen, Lougheed, Kathryn E.A., Osborne, Simon A., Saxty, Barbara, Smerdon, Stephen J., Taylor, Debra L., Whalley, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ltd 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368261/
https://www.ncbi.nlm.nih.gov/pubmed/22469702
http://dx.doi.org/10.1016/j.bmcl.2012.02.107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368261/
https://www.ncbi.nlm.nih.gov/pubmed/22469702
http://dx.doi.org/10.1016/j.bmcl.2012.02.107

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