The crystal structure of Leishmania major N(5),N(10)-methylenetetrahydrofolate dehydrogenase/cyclohydrolase and assessment of a potential drug target()

Three enzyme activities in the protozoan Leishmania major, namely N(5),N(10)-methylenetetrahydrofolate dehydrogenase/N(5),N(10)-methenyltetrahydrofolate cyclohydrolase (DHCH) and N(10)-formyltetrahydrofolate ligase (FTL) produce the essential intermediate N(10)-formyltetrahydrofolate. Although trypa...

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Detalles Bibliográficos
Autores principales: Eadsforth, Thomas C., Cameron, Scott, Hunter, William N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier/North-Holland Biomedical Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368264/
https://www.ncbi.nlm.nih.gov/pubmed/22108435
http://dx.doi.org/10.1016/j.molbiopara.2011.11.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368264/
https://www.ncbi.nlm.nih.gov/pubmed/22108435
http://dx.doi.org/10.1016/j.molbiopara.2011.11.004

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