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Rank Signaling Links the Development of Invariant γδ T Cell Progenitors and Aire(+) Medullary Epithelium

The thymic medulla provides a specialized microenvironment for the negative selection of T cells, with the presence of autoimmune regulator (Aire)-expressing medullary thymic epithelial cells (mTECs) during the embryonic-neonatal period being both necessary and sufficient to establish long-lasting t...

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Detalles Bibliográficos
Autores principales: Roberts, Natalie A., White, Andrea J., Jenkinson, William E., Turchinovich, Gleb, Nakamura, Kyoko, Withers, David R., McConnell, Fiona M., Desanti, Guillaume E., Benezech, Cecile, Parnell, Sonia M., Cunningham, Adam F., Paolino, Magdalena, Penninger, Josef M., Simon, Anna Katharina, Nitta, Takeshi, Ohigashi, Izumi, Takahama, Yousuke, Caamano, Jorge H., Hayday, Adrian C., Lane, Peter J.L., Jenkinson, Eric J., Anderson, Graham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368267/
https://www.ncbi.nlm.nih.gov/pubmed/22425250
http://dx.doi.org/10.1016/j.immuni.2012.01.016