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Rank Signaling Links the Development of Invariant γδ T Cell Progenitors and Aire(+) Medullary Epithelium
The thymic medulla provides a specialized microenvironment for the negative selection of T cells, with the presence of autoimmune regulator (Aire)-expressing medullary thymic epithelial cells (mTECs) during the embryonic-neonatal period being both necessary and sufficient to establish long-lasting t...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368267/ https://www.ncbi.nlm.nih.gov/pubmed/22425250 http://dx.doi.org/10.1016/j.immuni.2012.01.016 |