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Rank Signaling Links the Development of Invariant γδ T Cell Progenitors and Aire(+) Medullary Epithelium
The thymic medulla provides a specialized microenvironment for the negative selection of T cells, with the presence of autoimmune regulator (Aire)-expressing medullary thymic epithelial cells (mTECs) during the embryonic-neonatal period being both necessary and sufficient to establish long-lasting t...
Autores principales: | Roberts, Natalie A., White, Andrea J., Jenkinson, William E., Turchinovich, Gleb, Nakamura, Kyoko, Withers, David R., McConnell, Fiona M., Desanti, Guillaume E., Benezech, Cecile, Parnell, Sonia M., Cunningham, Adam F., Paolino, Magdalena, Penninger, Josef M., Simon, Anna Katharina, Nitta, Takeshi, Ohigashi, Izumi, Takahama, Yousuke, Caamano, Jorge H., Hayday, Adrian C., Lane, Peter J.L., Jenkinson, Eric J., Anderson, Graham |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368267/ https://www.ncbi.nlm.nih.gov/pubmed/22425250 http://dx.doi.org/10.1016/j.immuni.2012.01.016 |
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