The Anticholinesterase Phenserine and Its Enantiomer Posiphen as 5′Untranslated-Region-Directed Translation Blockers of the Parkinson's Alpha Synuclein Expression

There is compelling support for limiting expression of alpha-synuclein (α-syn) in the brains of Parkinson's disease (PD) patients. An increase of SNCA gene copy number can genetically cause familial PD where increased dose of this pathogenic protein correlates with severity of symptoms (triplic...

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Detalles Bibliográficos
Autores principales: Mikkilineni, Sohan, Cantuti-Castelvetri, Ippolita, Cahill, Catherine M., Balliedier, Amelie, Greig, Nigel H., Rogers, Jack T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368596/
https://www.ncbi.nlm.nih.gov/pubmed/22693681
http://dx.doi.org/10.1155/2012/142372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368596/
https://www.ncbi.nlm.nih.gov/pubmed/22693681
http://dx.doi.org/10.1155/2012/142372

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