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Ubiquitination is involved in secondary growth, not initial formation of polyglutamine protein aggregates in C. elegans
BACKGROUND: Protein misfolding and subsequent aggregation are hallmarks of several human diseases. The cell has a variety of mechanisms for coping with misfolded protein stress, including ubiquitin-mediated protein degradation. In fact, the presence of ubiquitin at protein aggregates is a common fea...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368771/ https://www.ncbi.nlm.nih.gov/pubmed/22494772 http://dx.doi.org/10.1186/1471-2121-13-10 |