Plakophilin3 Loss Leads to an Increase in PRL3 Levels Promoting K8 Dephosphorylation, Which Is Required for Transformation and Metastasis

The desmosome anchors keratin filaments in epithelial cells leading to the formation of a tissue wide IF network. Loss of the desmosomal plaque protein plakophilin3 (PKP3) in HCT116 cells, leads to an increase in neoplastic progression and metastasis, which was accompanied by an increase in K8 level...

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Detalles Bibliográficos
Autores principales: Khapare, Nileema, Kundu, Samrat T., Sehgal, Lalit, Sawant, Mugdha, Priya, Rashmi, Gosavi, Prajakta, Gupta, Neha, Alam, Hunain, Karkhanis, Madhura, Naik, Nishigandha, Vaidya, Milind M., Dalal, Sorab N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368841/
https://www.ncbi.nlm.nih.gov/pubmed/22701666
http://dx.doi.org/10.1371/journal.pone.0038561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368841/
https://www.ncbi.nlm.nih.gov/pubmed/22701666
http://dx.doi.org/10.1371/journal.pone.0038561

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