A Simple Method for Analyzing Exome Sequencing Data Shows Distinct Levels of Nonsynonymous Variation for Human Immune and Nervous System Genes

To measure the strength of natural selection that acts upon single nucleotide variants (SNVs) in a set of human genes, we calculate the ratio between nonsynonymous SNVs (nsSNVs) per nonsynonymous site and synonymous SNVs (sSNVs) per synonymous site. We transform this ratio with a respective factor f...

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Detalles Bibliográficos
Autores principales: Freudenberg, Jan, Gregersen, Peter K., Freudenberg-Hua, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368947/
https://www.ncbi.nlm.nih.gov/pubmed/22701602
http://dx.doi.org/10.1371/journal.pone.0038087

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368947/
https://www.ncbi.nlm.nih.gov/pubmed/22701602
http://dx.doi.org/10.1371/journal.pone.0038087

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