Cargando…

Inhibition of Gene Expression of Organic Cation/Carnitine Transporter and Antioxidant Enzymes in Oxazaphosphorines-Induced Acute Cardiomyopathic Rat Models

It is well documented that high therapeutic doses of oxazaphosphorines, cyclophosphamide (CP) and ifosfamide (IFO), are associated with cardiomyopathy. This study investigated whether oxazaphosphorines alter the expression of organic cation/carnitine transporter (OCTN2) and antioxidant genes and if...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sayed-Ahmed, Mohamed M., Aldelemy, Meshan Lafi, Hafez, Mohamed M., Al-Shabanah, Othman A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369488/ https://www.ncbi.nlm.nih.gov/pubmed/22701146 http://dx.doi.org/10.1155/2012/452902

Ejemplares similares

Downregulation of Oxidative and Nitrosative Apoptotic Signaling by L-Carnitine in Ifosfamide-Induced Fanconi Syndrome Rat Model
por: Sayed-Ahmed, Mohamed M., et al.
Publicado: (2012)

Carnitine Supplementation Attenuates Sunitinib-Induced Inhibition of AMP-Activated Protein Kinase Downstream Signals in Cardiac Tissues
por: Sayed-Ahmed, Mohamed M., et al.
Publicado: (2019)

Doxorubicin Toxicity can be Ameliorated during Antioxidant L-Carnitine Supplementation
por: Alshabanah, Othman A., et al.
Publicado: (2010)

Cholesterol stimulates the cellular uptake of L-carnitine by the carnitine/organic cation transporter novel 2 (OCTN2)
por: Zhang, Lu, et al.
Publicado: (2021)

Oxazaphosphorines combined with immune checkpoint blockers: dose-dependent tuning between immune and cytotoxic effects
por: Delahousse, Julia, et al.
Publicado: (2020)

Thymoquinone attenuates diethylnitrosamine induction of hepatic carcinogenesis through antioxidant signaling
por: Sayed-Ahmed, Mohamed M, et al.
Publicado: (2010)

Protective effect of rutin on the antioxidant genes expression in hypercholestrolemic male Westar rat
por: Al-Rejaie, Salem S, et al.
Publicado: (2013)

The effect of myosin RLC phosphorylation in normal and cardiomyopathic mouse hearts
por: Muthu, Priya, et al.
Publicado: (2012)

Different Involvement of Promoter Methylation in the Expression of Organic Cation/Carnitine Transporter 2 (OCTN2) in Cancer Cell Lines
por: Qu, Qiang, et al.
Publicado: (2013)

Organic cation/carnitine transporter (OCTN2) interaction proteome in rat astrocytes: Role of phosphatase PP2A
por: Nalecz, Katarzyna, et al.
Publicado: (2015)

Carnitine/organic cation transporter 1 precipitates the progression of interstitial fibrosis through oxidative stress in diabetic nephropathy in mice
por: Makiishi, Shohei, et al.
Publicado: (2021)

Anti-metastatic and anti-proliferative activity of eugenol against triple negative and HER2 positive breast cancer cells
por: Abdullah, Mashan L., et al.
Publicado: (2018)

Eugenol-Induced Autophagy and Apoptosis in Breast Cancer Cells via PI3K/AKT/FOXO3a Pathway Inhibition
por: Abdullah, Mashan L., et al.
Publicado: (2021)

Effects of Cholinergic Stimulation with Pyridostigmine Bromide on Chronic Chagasic Cardiomyopathic Mice
por: de Cuba, Marília Beatriz, et al.
Publicado: (2014)

Cardiomyopathic troponin mutations predominantly occur at its interface with actin and tropomyosin
por: Tobacman, Larry S., et al.
Publicado: (2021)

The Role of the Carnitine/Organic Cation Transporter Novel 2 in the Clinical Outcome of Patients With Locally Advanced Esophageal Carcinoma Treated With Oxaliplatin
por: Sun, Dongfeng, et al.
Publicado: (2021)

Association between Paraoxonases Gene Expression and Oxidative Stress in Hepatotoxicity Induced by CCl(4)
por: Hafez, Mohamed M., et al.
Publicado: (2014)

Protective Effects of Aspirin from Cardiac Hypertrophy and Oxidative Stress in Cardiomyopathic Hamsters
por: Wu, Rong, et al.
Publicado: (2012)

Structural and protein interaction effects of hypertrophic and dilated cardiomyopathic mutations in alpha-tropomyosin
por: Chang, Audrey N., et al.
Publicado: (2014)

Human papillomavirus genotyping and integration in ovarian cancer Saudi patients
por: Al-Shabanah, Othman A, et al.
Publicado: (2013)

Effects of 1α,25-dihydroxyvitamin D(3) on the pharmacokinetics and biodistribution of ergothioneine, an endogenous organic cation/carnitine transporter 1 substrate, in rats
por: Vo, Dang-Khoa, et al.
Publicado: (2022)

The antioxidant properties of carnitine in vitro
por: Solarska, Katarzyna, et al.
Publicado: (2009)

Regional rotation of the left ventricle in healthy and cardiomyopathic subjects measured with radial myocardial tagging
por: Kaveh, Razieh, et al.
Publicado: (2014)

Modulation of Vascular ACE by Oxidative Stress in Young Syrian Cardiomyopathic Hamsters: Therapeutic Implications
por: Cruz, Nildris, et al.
Publicado: (2016)

Desferrioxamine Attenuates Doxorubicin-Induced Acute Cardiotoxicity through TFG-β/Smad p53 Pathway in Rat Model
por: Al-Shabanah, Othman A., et al.
Publicado: (2012)

Caveolin-1 - A Novel Interacting Partner of Organic Cation/Carnitine Transporter (Octn2): Effect of Protein Kinase C on This Interaction in Rat Astrocytes
por: Czeredys, Magdalena, et al.
Publicado: (2013)

BH4 activates CaMKK2 and rescues the cardiomyopathic phenotype in rodent models of diabetes
por: Kim, Hyoung Kyu, et al.
Publicado: (2020)

Myocardial Stiffness Evaluation Using Noninvasive Shear Wave Imaging in Healthy and Hypertrophic Cardiomyopathic Adults
por: Villemain, Olivier, et al.
Publicado: (2019)

Cardiomyopathic mutations in essential light chain reveal mechanisms regulating the super relaxed state of myosin
por: Sitbon, Yoel H., et al.
Publicado: (2021)

Optical ventricular cardioversion by local optogenetic targeting and LED implantation in a cardiomyopathic rat model
por: Nyns, Emile C A, et al.
Publicado: (2021)

Interaction of Masitinib with Organic Cation Transporters
por: Harrach, Saliha, et al.
Publicado: (2022)

Carvedilol-Afforded Protection against Daunorubicin-Induced Cardiomyopathic Rats In Vivo: Effects on Cardiac Fibrosis and Hypertrophy
por: Arozal, Wawaimuli, et al.
Publicado: (2011)

An mRNA assay system demonstrates proteasomal-specific degradation contributes to cardiomyopathic phospholamban null mutation
por: Rohner, Eduarde, et al.
Publicado: (2021)

Residual OCTN2 transporter activity, carnitine levels and symptoms correlate in patients with primary carnitine deficiency
por: Rasmussen, Jan, et al.
Publicado: (2014)

Hepato-protective effect of rutin via IL-6/STAT3 pathway in CCl(4)-induced hepatotoxicity in rats
por: Hafez, Mohamed M., et al.
Publicado: (2015)

Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations
por: Ciarimboli, Giuliano
Publicado: (2021)

Atypical Substrates of the Organic Cation Transporter 1
por: Redeker, Kyra-Elisa Maria, et al.
Publicado: (2022)

Regulation of Transporters for Organic Cations by High Glucose
por: Steinbüchel, Martin, et al.
Publicado: (2023)

Structural basis of promiscuous substrate transport by Organic Cation Transporter 1
por: Zeng, Yi C., et al.
Publicado: (2023)

A hypertrophic and dilated cardiomyopathic sudden cardiac death case; de novo mutations in TTN and SGCD genes
por: Baydar, Çetin Lütfi, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_tc3c5cio9q8ige6mg15qn6nlr5