DNA fragments binding CTCF in vitro and in vivo are capable of blocking enhancer activity

BACKGROUND: Earlier we identified ten 100-300-bp long CTCF-binding DNA fragments selected earlier from a 1-Mb human chromosome 19 region. Here the positive-negative selection technique was used to check the ability of CTCF-binding human genomic fragments to block enhancer-promoter interaction when i...

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Detalles Bibliográficos
Autores principales: Didych, Dmitry A, Kotova, Elena S, Akopov, Segey B, Nikolaev, Lev G, Sverdlov, Eugene D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369819/
https://www.ncbi.nlm.nih.gov/pubmed/22480385
http://dx.doi.org/10.1186/1756-0500-5-178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369819/
https://www.ncbi.nlm.nih.gov/pubmed/22480385
http://dx.doi.org/10.1186/1756-0500-5-178

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