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In-Silico screening of Pleconaril and its novel substituted derivatives with Neuraminidase of H1N1 Influenza strain

BACKGROUND: Neuraminidase (NA) is a prominent surface antigen of Influenza viruses, which helps in release of viruses from the host cells after replication. Anti influenza drugs such as Oseltamivir target a highly conserved active site of NA, which comprises of 8 functional residues (R118, D151, R15...

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Detalles Bibliográficos
Autores principales: Hussain Basha, Syed, Prasad, R Nalini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369820/
https://www.ncbi.nlm.nih.gov/pubmed/22340192
http://dx.doi.org/10.1186/1756-0500-5-105