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AAV2-Mediated Combined Subretinal Delivery of IFN-α and IL-4 Reduces the Severity of Experimental Autoimmune Uveoretinitis

We previously showed that adeno-associated virus 2 (AAV2) mediated subretinal delivery of human interferon-alpha (IFN-α) could effectively inhibit experimental autoimmune uveoretinitis (EAU). In this study we investigated whether subretinal injection of both AVV2.IFN-α and AAV2.IL-4 had a stronger i...

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Detalles Bibliográficos
Autores principales: Tian, Lichun, Lei, Bo, Shao, Ju, Wei, Lin, Kijlstra, Aize, Yang, Peizeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369876/
https://www.ncbi.nlm.nih.gov/pubmed/22685550
http://dx.doi.org/10.1371/journal.pone.0037995