Cargando…
Propagation of RML Prions in Mice Expressing PrP Devoid of GPI Anchor Leads to Formation of a Novel, Stable Prion Strain
PrP(C), a host protein which in prion-infected animals is converted to PrP(Sc), is linked to the cell membrane by a GPI anchor. Mice expressing PrP(C) without GPI anchor (tgGPI(-) mice), are susceptible to prion infection but accumulate anchorless PrP(Sc) extra-, rather than intracellularly. We inve...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369955/ https://www.ncbi.nlm.nih.gov/pubmed/22685404 http://dx.doi.org/10.1371/journal.ppat.1002746 |