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Propagation of RML Prions in Mice Expressing PrP Devoid of GPI Anchor Leads to Formation of a Novel, Stable Prion Strain
PrP(C), a host protein which in prion-infected animals is converted to PrP(Sc), is linked to the cell membrane by a GPI anchor. Mice expressing PrP(C) without GPI anchor (tgGPI(-) mice), are susceptible to prion infection but accumulate anchorless PrP(Sc) extra-, rather than intracellularly. We inve...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369955/ https://www.ncbi.nlm.nih.gov/pubmed/22685404 http://dx.doi.org/10.1371/journal.ppat.1002746 |