Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner

The blood vessels of cancerous tumours are leaky(1–3) and poorly organized(4–7). This can increase the interstitial fluid pressure (IFP) inside tumours and reduce blood supply to them, which impairs drug delivery(8–9). Anti-angiogenic therapies – which “normalize” the abnormal blood vessels in tumou...

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Detalles Bibliográficos
Autores principales: Chauhan, Vikash P., Stylianopoulos, Triantafyllos, Martin, John D., Popović, Zoran, Chen, Ou, Kamoun, Walid S., Bawendi, Moungi G., Fukumura, Dai, Jain, Rakesh K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370066/
https://www.ncbi.nlm.nih.gov/pubmed/22484912
http://dx.doi.org/10.1038/nnano.2012.45

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370066/
https://www.ncbi.nlm.nih.gov/pubmed/22484912
http://dx.doi.org/10.1038/nnano.2012.45

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