Orexin Receptor Antagonism, a New Sleep-Enabling Paradigm: A Proof-of-Concept Clinical Trial

The orexin system is a key regulator of sleep and wakefulness. In a multicenter, double-blind, randomized, placebo-controlled, two-way crossover study, 161 primary insomnia patients received either the dual orexin receptor antagonist almorexant, at 400, 200, 100, or 50 mg in consecutive stages, or p...

Descripción completa

Detalles Bibliográficos
Autores principales: Hoever, P, Dorffner, G, Beneš, H, Penzel, T, Danker-Hopfe, H, Barbanoj, M J, Pillar, G, Saletu, B, Polo, O, Kunz, D, Zeitlhofer, J, Berg, S, Partinen, M, Bassetti, C L, Högl, B, Ebrahim, I O, Holsboer-Trachsler, E, Bengtsson, H, Peker, Y, Hemmeter, U-M, Chiossi, E, Hajak, G, Dingemanse, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Clinical Trials
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370822/
https://www.ncbi.nlm.nih.gov/pubmed/22549286
http://dx.doi.org/10.1038/clpt.2011.370

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370822/
https://www.ncbi.nlm.nih.gov/pubmed/22549286
http://dx.doi.org/10.1038/clpt.2011.370

Ejemplares similares