Orexin Receptor Antagonism, a New Sleep-Enabling Paradigm: A Proof-of-Concept Clinical Trial

The orexin system is a key regulator of sleep and wakefulness. In a multicenter, double-blind, randomized, placebo-controlled, two-way crossover study, 161 primary insomnia patients received either the dual orexin receptor antagonist almorexant, at 400, 200, 100, or 50 mg in consecutive stages, or p...

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Detalles Bibliográficos
Autores principales: Hoever, P, Dorffner, G, Beneš, H, Penzel, T, Danker-Hopfe, H, Barbanoj, M J, Pillar, G, Saletu, B, Polo, O, Kunz, D, Zeitlhofer, J, Berg, S, Partinen, M, Bassetti, C L, Högl, B, Ebrahim, I O, Holsboer-Trachsler, E, Bengtsson, H, Peker, Y, Hemmeter, U-M, Chiossi, E, Hajak, G, Dingemanse, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Clinical Trials
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370822/
https://www.ncbi.nlm.nih.gov/pubmed/22549286
http://dx.doi.org/10.1038/clpt.2011.370

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