Histone deacetylase inhibitors suppress mutant p53 transcription via histone deacetylase 8

Mutation of the p53 gene is the most common genetic alteration in human cancer and contributes to malignant process by enhancing transformed properties of cells and resistance to anticancer therapy. Mutant p53 is often highly expressed in tumor cells at least in part due to its increased half-life....

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Detalles Bibliográficos
Autores principales: Yan, Wensheng, Liu, Shou, Xu, Enshun, Zhang, Jin, Zhang, Yanhong, Chen, Xiufang, Chen, Xinbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371110/
https://www.ncbi.nlm.nih.gov/pubmed/22391568
http://dx.doi.org/10.1038/onc.2012.81

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371110/
https://www.ncbi.nlm.nih.gov/pubmed/22391568
http://dx.doi.org/10.1038/onc.2012.81

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