Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses

β-Adrenoceptor antagonists differ in their degree of partial agonism. In vitro assays have provided information on ligand affinity, selectivity, and intrinsic efficacy. However, the extent to which these properties are manifest in vivo is less clear. Conscious freely moving rats, instrumented for me...

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Detalles Bibliográficos
Autores principales: Baker, Jillian G., Kemp, Philip, March, Julie, Fretwell, Laurice, Hill, Stephen J., Gardiner, Sheila M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of American Societies for Experimental Biology 2011
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371235/
https://www.ncbi.nlm.nih.gov/pubmed/21865315
http://dx.doi.org/10.1096/fj.11-192435

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371235/
https://www.ncbi.nlm.nih.gov/pubmed/21865315
http://dx.doi.org/10.1096/fj.11-192435

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