Loss of Ercc1 Results in a Time- and Dose-Dependent Reduction of Proliferating Early Hematopoietic Progenitors

The endonuclease complex Ercc1/Xpf is involved in interstrand crosslink repair and functions downstream of the Fanconi pathway. Loss of Ercc1 causes hematopoietic defects similar to those seen in Fanconi Anemia. Ercc1 (−/−) mice die 3-4 weeks after birth, which prevents long-term follow up of the he...

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Detalles Bibliográficos
Autores principales: Verhagen-Oldenampsen, Judith H. E., Haanstra, Jurgen R., van Strien, Paulina M. H., Valkhof, Marijke, Touw, Ivo P., von Lindern, Marieke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371671/
https://www.ncbi.nlm.nih.gov/pubmed/22701168
http://dx.doi.org/10.1155/2012/783068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371671/
https://www.ncbi.nlm.nih.gov/pubmed/22701168
http://dx.doi.org/10.1155/2012/783068

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