Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2

Programmed cell death 1 (PD-1) is a negative costimulatory receptor critical for the suppression of T cell activation in vitro and in vivo. Single cell imaging elucidated a molecular mechanism of PD-1–mediated suppression. PD-1 becomes clustered with T cell receptors (TCRs) upon binding to its ligan...

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Detalles Bibliográficos
Autores principales: Yokosuka, Tadashi, Takamatsu, Masako, Kobayashi-Imanishi, Wakana, Hashimoto-Tane, Akiko, Azuma, Miyuki, Saito, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371732/
https://www.ncbi.nlm.nih.gov/pubmed/22641383
http://dx.doi.org/10.1084/jem.20112741

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371732/
https://www.ncbi.nlm.nih.gov/pubmed/22641383
http://dx.doi.org/10.1084/jem.20112741

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