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A strand specific high resolution normalization method for chip-sequencing data employing multiple experimental control measurements
BACKGROUND: High-throughput sequencing is becoming the standard tool for investigating protein-DNA interactions or epigenetic modifications. However, the data generated will always contain noise due to e.g. repetitive regions or non-specific antibody interactions. The noise will appear in the form o...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371767/ https://www.ncbi.nlm.nih.gov/pubmed/22248020 http://dx.doi.org/10.1186/1748-7188-7-2 |