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Recognition models to predict DNA-binding specificities of homeodomain proteins

Motivation: Recognition models for protein-DNA interactions, which allow the prediction of specificity for a DNA-binding domain based only on its sequence or the alteration of specificity through rational design, have long been a goal of computational biology. There has been some progress in constru...

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Detalles Bibliográficos
Autores principales: Christensen, Ryan G., Enuameh, Metewo Selase, Noyes, Marcus B., Brodsky, Michael H., Wolfe, Scot A., Stormo, Gary D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371834/
https://www.ncbi.nlm.nih.gov/pubmed/22689783
http://dx.doi.org/10.1093/bioinformatics/bts202