Expression of aromatase and estrogen receptor alpha in chondrosarcoma, but no beneficial effect of inhibiting estrogen signaling both in vitro and in vivo

BACKGROUND: Chondrosarcomas are malignant cartilage-forming tumors which are highly resistant to conventional chemotherapy and radiotherapy. Estrogen signaling is known to play an important role in proliferation and differentiation of chondrocytes and in growth plate regulation at puberty. Our exper...

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Detalles Bibliográficos
Autores principales: Meijer, Danielle, Gelderblom, Hans, Karperien, Marcel, Cleton-Jansen, Anne-Marie, Hogendoorn, Pancras CW, Bovée, Judith VMG
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372281/
https://www.ncbi.nlm.nih.gov/pubmed/22613849
http://dx.doi.org/10.1186/2045-3329-1-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372281/
https://www.ncbi.nlm.nih.gov/pubmed/22613849
http://dx.doi.org/10.1186/2045-3329-1-5

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