Cargando…

Expression of aromatase and estrogen receptor alpha in chondrosarcoma, but no beneficial effect of inhibiting estrogen signaling both in vitro and in vivo

BACKGROUND: Chondrosarcomas are malignant cartilage-forming tumors which are highly resistant to conventional chemotherapy and radiotherapy. Estrogen signaling is known to play an important role in proliferation and differentiation of chondrocytes and in growth plate regulation at puberty. Our exper...

Descripción completa

Detalles Bibliográficos
Autores principales:	Meijer, Danielle, Gelderblom, Hans, Karperien, Marcel, Cleton-Jansen, Anne-Marie, Hogendoorn, Pancras CW, Bovée, Judith VMG
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372281/ https://www.ncbi.nlm.nih.gov/pubmed/22613849 http://dx.doi.org/10.1186/2045-3329-1-5

Ejemplares similares

Central chondrosarcoma progression is associated with pRb pathway alterations: CDK4 down-regulation and p16 overexpression inhibit cell growth in vitro
por: Schrage, Yvonne M, et al.
Publicado: (2009)

Non‐ossifying fibroma: A RAS‐MAPK driven benign bone neoplasm
por: Bovée, Judith VMG, et al.
Publicado: (2019)

Three new chondrosarcoma cell lines: one grade III conventional central chondrosarcoma and two dedifferentiated chondrosarcomas of bone
por: van Oosterwijk, Jolieke G, et al.
Publicado: (2012)

Opening the archives for state of the art tumour genetic research: sample processing for array-CGH using decalcified, formalin-fixed, paraffin-embedded tissue-derived DNA samples
por: de Jong, Danielle, et al.
Publicado: (2011)

Comprehensive analysis of published studies involving systemic treatment for chondrosarcoma of bone between 2000 and 2013
por: van Maldegem, Annemiek M, et al.
Publicado: (2014)

Multiple Osteochondromas: Clinicopathological and Genetic Spectrum and Suggestions for Clinical Management
por: Hameetman, Liesbeth, et al.
Publicado: (2004)

BMP and TGFbeta pathways in human central chondrosarcoma: enhanced endoglin and Smad 1 signaling in high grade tumors
por: Boeuf, Stephane, et al.
Publicado: (2012)

Peripheral chondrosarcoma progression is associated with increased type X collagen and vascularisation
por: de Andrea, Carlos E., et al.
Publicado: (2011)

Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and Casein Kinase II inhibition as a potential treatment option
por: Willems, Stefan M, et al.
Publicado: (2010)

Pharmacological inhibition of Bcl-xL sensitizes osteosarcoma to doxorubicin
por: Baranski, Zuzanna, et al.
Publicado: (2015)

Inhibitory effects of aromatase inhibitor on estrogen receptor-alpha positive ovarian cancer in mice
por: Hirakawa, Hachidai, et al.
Publicado: (2014)

The beneficial androgenic action of steroidal aromatase inactivators in estrogen-dependent breast cancer after failure of nonsteroidal drugs
por: Gao, Lanyang, et al.
Publicado: (2019)

Genome-wide analysis of Ollier disease: Is it all in the genes?
por: Pansuriya, Twinkal C, et al.
Publicado: (2011)

The Aromatase–Estrogen System in the Testes of Non-Mammalian Vertebrates
por: Rosati, Luigi, et al.
Publicado: (2021)

The Impact of Estrogen and Estrogen-Like Molecules in Neurogenesis and Neurodegeneration: Beneficial or Harmful?
por: Bustamante-Barrientos, Felipe A., et al.
Publicado: (2021)

Aromatase expression and role of estrogens in male gonad : a review
por: Carreau, Serge, et al.
Publicado: (2003)

Articular cartilage chondrocytes express aromatase and use enzymes involved in estrogen metabolism
por: Schicht, Martin, et al.
Publicado: (2014)

The oncometabolite D-2-hydroxyglutarate induced by mutant IDH1 or -2 blocks osteoblast differentiation in vitro and in vivo
por: Suijker, Johnny, et al.
Publicado: (2015)

Osteosarcoma Models: From Cell Lines to Zebrafish
por: Mohseny, Alexander B., et al.
Publicado: (2012)

Upregulation of an estrogen receptor-regulated gene by first generation progestins requires both the progesterone receptor and estrogen receptor alpha
por: Perkins, Meghan S., et al.
Publicado: (2022)

Both Nuclear and Membrane Estrogen Receptor Alpha Impact the Expression of Estrogen Receptors and Plasticity Markers in the Mouse Hypothalamus and Hippocampus
por: Mazid, Sanoara, et al.
Publicado: (2023)

Molecular pathology of sarcomas: concepts and clinical implications
por: Bovée, Judith V. M. G., et al.
Publicado: (2009)

Exploration of the chondrosarcoma metabolome; the mTOR pathway as an important pro-survival pathway
por: Addie, Ruben D., et al.
Publicado: (2019)

Effects of Estrogens on Adipokines and Glucose Homeostasis in Female Aromatase Knockout Mice
por: Van Sinderen, Michelle L., et al.
Publicado: (2015)

Molecular Basis for Endocrine Disruption by Pesticides Targeting Aromatase and Estrogen Receptor
por: Zhang, Chao, et al.
Publicado: (2020)

Estrogen disorders: Interpreting the abnormal regulation of aromatase in granulosa cells (Review)
por: Liu, Ting, et al.
Publicado: (2021)

Simultaneous Quantification of Aromatase Inhibitors and Estrogens in Postmenopausal Breast Cancer Patients
por: Bertelsen, Bjørn-Erik, et al.
Publicado: (2021)

Site-Specific Regulation of Sulfatase and Aromatase Pathways for Estrogen Production in Endometriosis
por: Da Costa, Katiane de Almeida, et al.
Publicado: (2022)

Testosterone-derived estradiol production by male endothelium is robust and dependent on p450 aromatase via estrogen receptor alpha
por: Villablanca, Amparo C, et al.
Publicado: (2013)

MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma
por: Sarver, Aaron L, et al.
Publicado: (2013)

MEK inhibition induces apoptosis in osteosarcoma cells with constitutive ERK1/2 phosphorylation
por: Baranski, Zuzanna, et al.
Publicado: (2015)

Mesenchymal stem cell transformation and sarcoma genesis
por: Xiao, Wei, et al.
Publicado: (2013)

The therapeutic target of estrogen receptor-alpha36 in estrogen-dependent tumors
por: Gu, Yu, et al.
Publicado: (2014)

Antitumor activity of Z-endoxifen in aromatase inhibitor-sensitive and aromatase inhibitor-resistant estrogen receptor-positive breast cancer
por: Jayaraman, Swaathi, et al.
Publicado: (2020)

Increased Sclerostin Levels after Further Ablation of Remnant Estrogen by Aromatase Inhibitors
por: Kim, Wonjin, et al.
Publicado: (2015)

Aromatase inhibition remodels the clonal architecture of estrogen-receptor-positive breast cancers
por: Miller, Christopher A., et al.
Publicado: (2016)

Estrogen receptors α and β and aromatase as independent predictors for prostate cancer outcome
por: Grindstad, Thea, et al.
Publicado: (2016)

Assessment of Five Pesticides as Endocrine-Disrupting Chemicals: Effects on Estrogen Receptors and Aromatase
por: Gea, Marta, et al.
Publicado: (2022)

The origins of estrogen receptor alpha-positive and estrogen receptor alpha-negative human breast cancer
por: Allred, D Craig, et al.
Publicado: (2004)

No preclinical rationale for IGF1R directed therapy in chondrosarcoma of bone
por: Peterse, Elisabeth F. P., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_a2l8e0ds0okcjr0us60i9khfds