Application of Consensus Scoring and Principal Component Analysis for Virtual Screening against β-Secretase (BACE-1)

BACKGROUND: In order to identify novel chemical classes of β-secretase (BACE-1) inhibitors, an alternative scoring protocol, Principal Component Analysis (PCA), was proposed to summarize most of the information from the original scoring functions and re-rank the results from the virtual screening ag...

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Detalles Bibliográficos
Autores principales: Liu, Shu, Fu, Rao, Zhou, Li-Hua, Chen, Sheng-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372491/
https://www.ncbi.nlm.nih.gov/pubmed/22701601
http://dx.doi.org/10.1371/journal.pone.0038086

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372491/
https://www.ncbi.nlm.nih.gov/pubmed/22701601
http://dx.doi.org/10.1371/journal.pone.0038086

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