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A Method to Find Longevity-Selected Positions in the Mammalian Proteome

Evolutionary theory suggests that the force of natural selection decreases with age. To explore the extent to which this prediction directly affects protein structure and function, we used multiple regression to find longevity-selected positions, defined as the columns of a sequence alignment conser...

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Detalles Bibliográficos
Autores principales: Semeiks, Jeremy, Grishin, Nick V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372525/
https://www.ncbi.nlm.nih.gov/pubmed/22701678
http://dx.doi.org/10.1371/journal.pone.0038595