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A Method to Find Longevity-Selected Positions in the Mammalian Proteome
Evolutionary theory suggests that the force of natural selection decreases with age. To explore the extent to which this prediction directly affects protein structure and function, we used multiple regression to find longevity-selected positions, defined as the columns of a sequence alignment conser...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372525/ https://www.ncbi.nlm.nih.gov/pubmed/22701678 http://dx.doi.org/10.1371/journal.pone.0038595 |