Dynamic and static components power unfolding in topologically closed rings of a AAA+ proteolytic machine

In the E. coli ClpXP protease, a hexameric ClpX ring couples ATP binding and hydrolysis to mechanical protein unfolding and translocation into the ClpP degradation chamber. Rigid-body packing between the small AAA+ domain of each ClpX subunit and the large AAA+ domain of its neighbor stabilizes the...

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Detalles Bibliográficos
Autores principales: Glynn, Steven E., Nager, Andrew R., Baker, Tania A., Sauer, Robert T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372766/
https://www.ncbi.nlm.nih.gov/pubmed/22562135
http://dx.doi.org/10.1038/nsmb.2288

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372766/
https://www.ncbi.nlm.nih.gov/pubmed/22562135
http://dx.doi.org/10.1038/nsmb.2288

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