Stable Expression of Recombinant Factor VIII in CHO Cells Using Methotrexate-Driven Transgene Amplification

Prophylaxis and treatment of inherited clotting disorder hemophilia A requires regular administration of factor VIII. Recombinant factor VIII, which is produced in CHO or BHK cells, is equivalent to the plasma-derived one and is prevalent in current clinical practice in developed countries. Developm...

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Detalles Bibliográficos
Autores principales: Orlova, N. A., Kovnir, S. V., Vorobiev, I. I., Yuriev, A.S., Gabibov, A.G., Vorobiev, A.I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372988/
https://www.ncbi.nlm.nih.gov/pubmed/22708069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372988/
https://www.ncbi.nlm.nih.gov/pubmed/22708069

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