Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production

Understanding the mechanisms that control processing of the amyloid precursor protein (APP) to produce amyloid-β (Aβ) peptide represents a key area of Alzheimer's disease research. Here, we show that siRNA-mediated loss of calsyntenin-1 in cultured neurons alters APP processing to increase prod...

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Detalles Bibliográficos
Autores principales: Vagnoni, Alessio, Perkinton, Michael S., Gray, Emma H., Francis, Paul T., Noble, Wendy, Miller, Christopher C.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373235/
https://www.ncbi.nlm.nih.gov/pubmed/22434822
http://dx.doi.org/10.1093/hmg/dds109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373235/
https://www.ncbi.nlm.nih.gov/pubmed/22434822
http://dx.doi.org/10.1093/hmg/dds109

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