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Canalization of the evolutionary trajectory of the human influenza virus

BACKGROUND: Since its emergence in 1968, influenza A (H3N2) has evolved extensively in genotype and antigenic phenotype. However, despite strong pressure to evolve away from human immunity and to diversify in antigenic phenotype, H3N2 influenza shows paradoxically limited genetic and antigenic diver...

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Detalles Bibliográficos
Autores principales: Bedford, Trevor, Rambaut, Andrew, Pascual, Mercedes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373370/
https://www.ncbi.nlm.nih.gov/pubmed/22546494
http://dx.doi.org/10.1186/1741-7007-10-38