High Expression of Wee1 Is Associated with Poor Disease-Free Survival in Malignant Melanoma: Potential for Targeted Therapy

Notoriously resistant malignant melanoma is one of the most increasing forms of cancer worldwide; there is thus a precarious need for new treatment options. The Wee1 kinase is a major regulator of the G(2)/M checkpoint, and halts the cell cycle by adding a negative phosphorylation on CDK1 (Tyr15). A...

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Detalles Bibliográficos
Autores principales: Magnussen, Gry Irene, Holm, Ruth, Emilsen, Elisabeth, Rosnes, Anne Katrine Ree, Slipicevic, Ana, Flørenes, Vivi Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373567/
https://www.ncbi.nlm.nih.gov/pubmed/22719872
http://dx.doi.org/10.1371/journal.pone.0038254

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373567/
https://www.ncbi.nlm.nih.gov/pubmed/22719872
http://dx.doi.org/10.1371/journal.pone.0038254

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