A series of Fas receptor agonist antibodies that demonstrate an inverse correlation between affinity and potency

Receptor agonism remains poorly understood at the molecular and mechanistic level. In this study, we identified a fully human anti-Fas antibody that could efficiently trigger apoptosis and therefore function as a potent agonist. Protein engineering and crystallography were used to mechanistically un...

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Detalles Bibliográficos
Autores principales: Chodorge, M, Züger, S, Stirnimann, C, Briand, C, Jermutus, L, Grütter, M G, Minter, R R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374083/
https://www.ncbi.nlm.nih.gov/pubmed/22261618
http://dx.doi.org/10.1038/cdd.2011.208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374083/
https://www.ncbi.nlm.nih.gov/pubmed/22261618
http://dx.doi.org/10.1038/cdd.2011.208

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