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A series of Fas receptor agonist antibodies that demonstrate an inverse correlation between affinity and potency
Receptor agonism remains poorly understood at the molecular and mechanistic level. In this study, we identified a fully human anti-Fas antibody that could efficiently trigger apoptosis and therefore function as a potent agonist. Protein engineering and crystallography were used to mechanistically un...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374083/ https://www.ncbi.nlm.nih.gov/pubmed/22261618 http://dx.doi.org/10.1038/cdd.2011.208 |