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Plk1 regulates the kinesin-13 protein Kif2b to promote faithful chromosome segregation

Solid tumors are frequently aneuploid, and many display high rates of ongoing chromosome missegregation in a phenomenon called chromosomal instability (CIN). The most common cause of CIN is the persistence of aberrant kinetochore-microtubule (k-MT) attachments, which manifest as lagging chromosomes...

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Detalles Bibliográficos
Autores principales: Hood, Emily A., Kettenbach, Arminja N., Gerber, Scott A., Compton, Duane A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374746/
https://www.ncbi.nlm.nih.gov/pubmed/22535524
http://dx.doi.org/10.1091/mbc.E11-12-1013