A Single E627K Mutation in the PB2 Protein of H9N2 Avian Influenza Virus Increases Virulence by Inducing Higher Glucocorticoids (GCs) Level

While repeated infection of humans and enhanced replication and transmission in mice has attracted more attention to it, the pathogenesis of H9N2 virus was less known in mice. PB(2) residue 627 as the virulent determinant of H5N1 virus is associated with systemic infection and impaired TCR activatio...

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Detalles Bibliográficos
Autores principales: Tian, Jin, Qi, Wenbao, Li, Xiaokang, He, Jun, Jiao, Peirong, Zhang, Changhui, Liu, Guo-Qian, Liao, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374829/
https://www.ncbi.nlm.nih.gov/pubmed/22719870
http://dx.doi.org/10.1371/journal.pone.0038233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374829/
https://www.ncbi.nlm.nih.gov/pubmed/22719870
http://dx.doi.org/10.1371/journal.pone.0038233

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