Mutations in LRP5 cause primary osteoporosis without features of OI by reducing Wnt signaling activity

BACKGROUND: Primary osteoporosis is a rare childhood-onset skeletal condition whose pathogenesis has been largely unknown. We have previously shown that primary osteoporosis can be caused by heterozygous missense mutations in the Low-density lipoprotein receptor-related protein 5 (LRP5) gene, and th...

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Detalles Bibliográficos
Autores principales: Korvala, Johanna, Jüppner, Harald, Mäkitie, Outi, Sochett, Etienne, Schnabel, Dirk, Mora, Stefano, Bartels, Cynthia F, Warman, Matthew L, Deraska, Donald, Cole, William G, Hartikka, Heini, Ala-Kokko, Leena, Männikkö, Minna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374890/
https://www.ncbi.nlm.nih.gov/pubmed/22487062
http://dx.doi.org/10.1186/1471-2350-13-26

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374890/
https://www.ncbi.nlm.nih.gov/pubmed/22487062
http://dx.doi.org/10.1186/1471-2350-13-26

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