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Self-tolerance in multiple sclerosis
During the last decade, several defects in self-tolerance have been identified in multiple sclerosis. Dysfunction in central tolerance leads to the thymic output of antigen-specific T cells with T cell receptor alterations favouring autoimmune reactions. In addition, premature thymic involution resu...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer Milan
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375076/ https://www.ncbi.nlm.nih.gov/pubmed/22450711 http://dx.doi.org/10.1007/s13760-012-0061-x |