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Na(+)/H(+)-exchanger-1 inhibition counteracts diabetic cataract formation and retinal oxidative-nitrative stress and apoptosis
The Na(+)-H(+)-exchanger-1 (NHE-1) controls intracellular pH and glycolytic enzyme activities, and its expression and activity are increased by diabetes and high glucose. NHE-1-dependent upregulation of the upper part of glycolysis, under conditions of inhibition (lens) or insufficient activation (r...
Autores principales: | LUPACHYK, SERGEY, STAVNIICHUK, ROMAN, KOMISSARENKO, JULIA I., DREL, VIKTOR R., OBROSOV, ALEXANDER A., EL-REMESSY, AZZA B., PACHER, PAL, OBROSOVA, IRINA G. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375174/ https://www.ncbi.nlm.nih.gov/pubmed/22407349 http://dx.doi.org/10.3892/ijmm.2012.933 |
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