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The Role of Non-Native Interactions in the Folding of Knotted Proteins

Stochastic simulations of coarse-grained protein models are used to investigate the propensity to form knots in early stages of protein folding. The study is carried out comparatively for two homologous carbamoyltransferases, a natively-knotted N-acetylornithine carbamoyltransferase (AOTCase) and an...

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Detalles Bibliográficos
Autores principales: Škrbić, Tatjana, Micheletti, Cristian, Faccioli, Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375218/
https://www.ncbi.nlm.nih.gov/pubmed/22719235
http://dx.doi.org/10.1371/journal.pcbi.1002504