Charge Profile Analysis Reveals That Activation of Pro-apoptotic Regulators Bax and Bak Relies on Charge Transfer Mediated Allosteric Regulation

The pro-apoptotic proteins Bax and Bak are essential for executing programmed cell death (apoptosis), yet the mechanism of their activation is not properly understood at the structural level. For the first time in cell death research, we calculated intra-protein charge transfer in order to study the...

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Detalles Bibliográficos
Autores principales: Ionescu, Crina-Maria, Svobodová Vařeková, Radka, Prehn, Jochen H. M., Huber, Heinrich J., Koča, Jaroslav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375244/
https://www.ncbi.nlm.nih.gov/pubmed/22719244
http://dx.doi.org/10.1371/journal.pcbi.1002565

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375244/
https://www.ncbi.nlm.nih.gov/pubmed/22719244
http://dx.doi.org/10.1371/journal.pcbi.1002565

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