Polymorphisms in the Mitochondrial Ribosome Recycling Factor EF-G2mt/MEF2 Compromise Cell Respiratory Function and Increase Atorvastatin Toxicity

Mitochondrial translation, essential for synthesis of the electron transport chain complexes in the mitochondria, is governed by nuclear encoded genes. Polymorphisms within these genes are increasingly being implicated in disease and may also trigger adverse drug reactions. Statins, a class of HMG-C...

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Detalles Bibliográficos
Autores principales: Callegari, Sylvie, Gregory, Philip A., Sykes, Matthew J., Bellon, Jennifer, Andrews, Stuart, McKinnon, Ross A., de Barros Lopes, Miguel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375252/
https://www.ncbi.nlm.nih.gov/pubmed/22719265
http://dx.doi.org/10.1371/journal.pgen.1002755

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375252/
https://www.ncbi.nlm.nih.gov/pubmed/22719265
http://dx.doi.org/10.1371/journal.pgen.1002755

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