TERRA Promotes Telomere Shortening through Exonuclease 1–Mediated Resection of Chromosome Ends

The long noncoding telomeric repeat containing RNA (TERRA) is expressed at chromosome ends. TERRA upregulation upon experimental manipulation or in ICF (immunodeficiency, centromeric instability, facial anomalies) patients correlates with short telomeres. To study the mechanism of telomere length co...

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Detalles Bibliográficos
Autores principales: Pfeiffer, Verena, Lingner, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375253/
https://www.ncbi.nlm.nih.gov/pubmed/22719262
http://dx.doi.org/10.1371/journal.pgen.1002747

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375253/
https://www.ncbi.nlm.nih.gov/pubmed/22719262
http://dx.doi.org/10.1371/journal.pgen.1002747

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