Engineering of Three-Finger Fold Toxins Creates Ligands with Original Pharmacological Profiles for Muscarinic and Adrenergic Receptors

Protein engineering approaches are often a combination of rational design and directed evolution using display technologies. Here, we test “loop grafting,” a rational design method, on three-finger fold proteins. These small reticulated proteins have exceptional affinity and specificity for their di...

Descripción completa

Detalles Bibliográficos
Autores principales: Fruchart-Gaillard, Carole, Mourier, Gilles, Blanchet, Guillaume, Vera, Laura, Gilles, Nicolas, Ménez, Renée, Marcon, Elodie, Stura, Enrico A., Servent, Denis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375269/
https://www.ncbi.nlm.nih.gov/pubmed/22720062
http://dx.doi.org/10.1371/journal.pone.0039166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375269/
https://www.ncbi.nlm.nih.gov/pubmed/22720062
http://dx.doi.org/10.1371/journal.pone.0039166

Ejemplares similares