Cardiac Transcription Factor Nkx2.5 Is Downregulated under Excessive O-GlcNAcylation Condition

Post-translational modification of proteins with O-linked N-acetylglucosamine (O-GlcNAc) is linked the development of diabetic cardiomyopathy. We investigated whether Nkx2.5 protein, a cardiac transcription factor, is regulated by O-GlcNAc. Recombinant Nkx2.5 (myc-Nkx2.5) proteins were reduced by tr...

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Detalles Bibliográficos
Autores principales: Kim, Hoe Suk, Woo, Ji Soo, Joo, Hyun Jung, Moon, Woo Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376112/
https://www.ncbi.nlm.nih.gov/pubmed/22719862
http://dx.doi.org/10.1371/journal.pone.0038053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376112/
https://www.ncbi.nlm.nih.gov/pubmed/22719862
http://dx.doi.org/10.1371/journal.pone.0038053

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